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Subpial transection surgery for epilepsy
| Content Provider | Scilit |
|---|---|
| Author | Krishnaiah, Balaji Ramaratnam, Sridharan Ranganathan, Lakshmi Narasimhan |
| Copyright Year | 2015 |
| Description | Journal: Cochrane Database of Systematic Reviews Nearly 30% of patients with epilepsy continue to have seizures in spite of using several antiepileptic drug (AED) regimens. Such patients are regarded as having refractory, or uncontrolled, epilepsy. No definition of uncontrolled, or medically refractory, epilepsy has been universally accepted, but for the purposes of this review, we will consider seizures as drug resistant if they have failed to respond to a minimum of two AEDs. It is believed that early surgical intervention may prevent seizures at a younger age, which, in turn, may improve the intellectual and social status of children. Many types of surgery are available for treatment of refractory epilepsy; one such procedure is known as subpial transection. To determine the benefits and adverse effects of subpial transection for partial-onset seizures and generalised tonic-clonic seizures in children and adults. We searched the Cochrane Epilepsy Group Specialised Register (29 June 2015), the Cochrane Central Register of Controlled Trials (CENTRAL; May 2015, Issue 5) and MEDLINE (1946 to 29 June 2015). We imposed no language restrictions. We considered all randomised and quasi-randomised parallel-group studies, whether blinded or non-blinded. Two review authors (BK and SR) independently screened trials identified by the search. The same two review authors planned to independently assess the methodological quality of studies. When studies were identified for inclusion, one review author would have extracted the data, and the other would have verified the data. We found no relevant studies. We found no evidence to support or refute use of subpial transection surgery for patients with medically refractory epilepsy. Well-designed randomised controlled trials are needed to guide clinical practice. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008153.pub3/pdf |
| ISSN | 1469493X |
| e-ISSN | 14651858 |
| DOI | 10.1002/14651858.cd008153.pub3 |
| Journal | Cochrane Database of Systematic Reviews |
| Issue Number | 12 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-12-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cochrane Database of Systematic Reviews Clinical Neurology |
| Content Type | Text |
| Resource Type | Article |
