Loading...
Please wait, while we are loading the content...
PDGF signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation
| Content Provider | Scilit |
|---|---|
| Author | Rezza, Amélie Sennett, Rachel Tanguy, Manon Clavel, Carlos Rendl, Michael |
| Copyright Year | 2015 |
| Description | Journal: Experimental Dermatology Embryonic hair follicle (HF) induction and formation is dependent on signalling crosstalk between the dermis and specialized dermal condensates on the mesenchymal side and epidermal cells and incipient placodes on the epithelial side, but the precise nature and succession of signals remain unclear. Platelet‐derived growth factor (PDGF) signalling is involved in the development of several organs and the maintenance of adult tissues, including HF regeneration in the hair cycle. As both PDGF receptors, PDGFRα and PDGFRβ, are expressed in embryonic dermis and dermal condensates, we explored in this study the role of PDGF signalling in HF induction and formation in the developing skin mesenchyme. We conditionally ablated both PDGF receptors with $Tbx18^{Cre}$ in early dermal condensates before follicle formation, and with Prx1‐Cre broadly in the ventral dermis prior to HF induction. In both PDGFR double mutants, HF induction and formation ensued normally, and the pattern of HF formation and HF numbers were unaffected. These data demonstrate that mesenchymal PDGF signalling, either in the specialized niche or broadly in the dermis, is dispensable for HF induction and formation. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943754/pdf |
| Ending Page | 470 |
| Page Count | 3 |
| Starting Page | 468 |
| e-ISSN | 16000625 |
| DOI | 10.1111/exd.12672 |
| Journal | Experimental Dermatology |
| Issue Number | 6 |
| Volume Number | 24 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-02-24 |
| Access Restriction | Open |
| Subject Keyword | Journal: Experimental Dermatology Developmental Biology Dermal Papilla Cells Hair Follicle Morphogenesis Hair Follicle Stem Cells Pdgf Signalling Stem Cell Niche |
| Content Type | Text |
