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A prospective, non comparative, multicenter study to investigate the effect of cadexomer iodine on bioburden load and other wound characteristics in diabetic foot ulcers
| Content Provider | Scilit |
|---|---|
| Author | Schwartz, Jamie A. Lantis, John C. Gendics, Cynthia Fuller, Amy M. Payne, Wyatt Ochs, Diane |
| Copyright Year | 2012 |
| Description | Journal: International Wound Journal Few studies regarding wound treatment with topical antimicrobials evaluate change in the bacterial bioburden of the wound with treatment. This study sought out to determine the in vivo effect of cadexomer iodine antibacterial dressing on diabetic foot ulcers (DFUs) that were infected or achieved a critical level of colonisation, looking specifically at wound progression in relation to bioburden. Fifteen patients corresponding to 16 total DFUs met criteria of displaying clinical signs of infection or critical colonisation and were suitable for a topical antibacterial dressing. They underwent weekly treatment for 6 weeks. Cultures were taken at week 0, 3 and 6 as appropriate. At week 6 median log10 bacterial count reduction of 1.0 was observed from baseline (p = 0·025). At week 3‐ a median log10 bacterial count reduction of 0.3 was observed from baseline (p = 0·049). Over the study period there was a 53.6% median reduction of the wound surface area. There were no patients that completely healed their ulcer over the 6 week study period. There was a statistically significant median reduction in the bacterial load over the 6 week period (p = 0·025) as well as 3 weeks (p = 0·049). This was accompanied by a median reduction of 53.6% in ulcer surface area and 50% in ulcer depth from baseline to final. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1742-481X.2012.01109.x/pdf |
| Ending Page | 199 |
| Page Count | 7 |
| Starting Page | 193 |
| ISSN | 17424801 |
| e-ISSN | 1742481X |
| DOI | 10.1111/j.1742-481x.2012.01109.x |
| Journal | International Wound Journal |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-11-09 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Wound Journal Diabetic Foot Ulcers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery Dermatology |
