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Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children
| Content Provider | Scilit |
|---|---|
| Author | Zand, Kevin A. Shah, Amol Heba, Elhamy Wolfson, Tanya Hamilton, Gavin Lam, Jessica Chen, Joshua Hooker, Jonathan C. Gamst, Anthony C. Middleton, Michael S. Schwimmer, Jeffrey B. Sirlin, Claude B. |
| Copyright Year | 2015 |
| Description | Journal: Journal of Magnetic Resonance Imaging (JMRI) To assess accuracy of magnitude-based magnetic resonance imaging (M-MRI) in children to estimate hepatic proton density fat fraction (PDFF) using two to six echoes, with magnetic resonance spectroscopy (MRS) -measured PDFF as a reference standard. This was an IRB-approved, HIPAA-compliant, single-center, cross-sectional, retrospective analysis of data collected prospectively between 2008 and 2013 in children with known or suspected nonalcoholic fatty liver disease (NAFLD). Two hundred eighty-six children (8-20 [mean 14.2 ± 2.5] years; 182 boys) underwent same-day MRS and M-MRI. Unenhanced two-dimensional axial spoiled gradient-recalled-echo images at six echo times were obtained at 3T after a single low-flip-angle (10°) excitation with ≥ 120-ms recovery time. Hepatic PDFF was estimated using the first two, three, four, five, and all six echoes. For each number of echoes, accuracy of M-MRI to estimate PDFF was assessed by linear regression with MRS-PDFF as reference standard. Accuracy metrics were regression intercept, slope, average bias, and R(2) . MRS-PDFF ranged from 0.2-40.4% (mean 13.1 ± 9.8%). Using three to six echoes, regression intercept, slope, and average bias were 0.46-0.96%, 0.99-1.01, and 0.57-0.89%, respectively. Using two echoes, these values were 2.98%, 0.97, and 2.72%, respectively. R(2) ranged 0.98-0.99 for all methods. Using three to six echoes, M-MRI has high accuracy for hepatic PDFF estimation in children. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592685/pdf |
| Ending Page | 1232 |
| Page Count | 10 |
| Starting Page | 1223 |
| e-ISSN | 15222586 |
| DOI | 10.1002/jmri.24888 |
| Journal | Journal of Magnetic Resonance Imaging (JMRI) |
| Issue Number | 5 |
| Volume Number | 42 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-04-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging Liver Steatosis Proton Density Fat Fraction |
| Content Type | Text |
| Resource Type | Article |
