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Sleep-disordered breathing in a general heart failure population: relationships to neurohumoral activation and subjective symptoms
| Content Provider | Scilit |
|---|---|
| Author | Rao, Archana Georgiadou, Panagiota Francis, Darrel P. Johnson, Andrew Kremastinos, Dimitris Th. Simonds, Anita K. Coats, Andrew J. S. Cowley, Alan Morrell, Mary J. |
| Copyright Year | 2006 |
| Description | Journal: Journal of Sleep Research The aim of this study was to determine the prevalence of sleep-related breathing disorders (SDB) in a UK general heart failure (HF) population, and assess its impact on neurohumoral markers and symptoms of sleepiness and quality of life. Eighty-four ambulatory patients (72 male, mean (SD) age 68.6 (10) yrs) attending UK HF clinics underwent an overnight recording of respiratory impedance, SaO2 and heart rate using a portable monitor (Nexan). Brain natriuretic peptide (BNP) and urinary catecholamines were measured. Subjective sleepiness and the impairment in quality of life were assessed (Epworth Sleepiness Scale (ESS), SF-36 Health Performance Score). SDB was classified using the Apnoea/Hypopnoea Index (AHI). The prevalence of SDB (AHI > 15 events h(-1)) was 24%, increasing from 15% in mild-to-moderate HF to 39% in severe HF. Patients with SDB had significantly higher levels of BNP and noradrenaline than those without SDB (mean (SD) BNP: 187 (119) versus 73 (98) pg mL(-1), P = 0.02; noradrenaline: 309 (183) versus 225 (148) nmol/24 h, P = 0.05). There was no significant difference in reported sleepiness or in any domain of SF-36, between groups with and without SDB (ESS: 7.8 (4.7) versus 7.5 (3.6), P = 0.87). In summary, in a general HF clinic population, the prevalence of SDB increased with the severity of HF. Patients with SDB had higher activation of a neurohumoral marker and more severe HF. Unlike obstructive sleep apnoea, SDB in HF had little discernible effect on sleepiness or quality of life as measured by standard subjective scales. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.2006.00494.x/pdf |
| Ending Page | 88 |
| Page Count | 8 |
| Starting Page | 81 |
| e-ISSN | 13652869 |
| DOI | 10.1111/j.1365-2869.2006.00494.x |
| Journal | Journal of Sleep Research |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Sleep Research Respiratory System Cheyne–stokes Respiration Heart Failure Sleep Apnoea Sleep‐disordered Breathing |
| Content Type | Text |
| Resource Type | Article |
