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Decrease of Atrial Natriuretic Peptide Content in Rat Superior Cervical Sympathetic Ganglion After Denervation and Axotomy
| Content Provider | Scilit |
|---|---|
| Author | Nagata, Yutaka Ebisu, Hiroshi Tamaru, Masao Fujita, Kimikazu Koide, Tadashi |
| Copyright Year | 1989 |
| Description | Journal: Journal of Neurochemistry We found atrial natriuretic peptide (ANP), known as a humoral factor in regulating body fluid volume and blood pressure, in considerable quantities in rat superior cervical sympathetic ganglion (SCG) by radioimmunoassay after separation with reverse-phase HPLC. Although the ANP content of the immature rat 1 week after birth was low, it doubled at 2 weeks and then increased gradually, until it reached the adult level. Denervation caused a rapid decrease in the ANP content to half of the intact SCG level after 3 h, which then fell to 10% of the control value on day 2 after operation. The time course of ANP content reduction after denervation was similar but rather faster than that of activity of the acetylcholine-synthesizing enzyme, choline acetyltransferase, an observation suggesting that ANP may partly contribute to cholinergic synaptic transmission. On the other hand, axotomy produced a rather slower decrease in the ANP content than did denervation. Enucleation and sialoadenectomy also caused a considerable reduction of the ANP content. Thus, part of the ANP found in the ganglion is apparently transported from sympathetically innervated extraganglionic organs via retrograde axoplasmic flow. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1989.tb09210.x/pdf |
| Ending Page | 1575 |
| Page Count | 6 |
| Starting Page | 1570 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1989.tb09210.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 5 |
| Volume Number | 52 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1989-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry Peripheral Vascular Disease Atrial Natriuretic Peptide Superior Cervical Sympathetic Ganglion Choline Acetyltransferase |
| Content Type | Text |
| Resource Type | Article |
