NDLI: Tight junctions on the move: molecular mechanisms for epithelial barrier regulation

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Tight junctions on the move: molecular mechanisms for epithelial barrier regulation

Content Provider	Scilit
Author	Shen, Le
Copyright Year	2012
Description	Journal: Annals of the New York Academy of Sciences Increasing evidence suggests that the tight junction is a dynamically regulated structure. Cytoskeletal reorganization, particularly myosin light chain phosphorylation‐‐induced actomyosin contraction, has increasingly been recognized as a mediator of physiological and pathophysiological tight junction regulation. However, our understanding of molecular mechanisms of tight junction modulation remains limited. Recent studies using live cell and live animal imaging techniques allowed us to peek into the molecular details of tight junction regulation. At resting conditions, the tight junction is maintained by dynamic protein–protein interactions, which may provide a platform for rapid tight junction regulation. Following stimulation, distinct forms of tight junction protein reorganization were observed. Tumor necrosis factor (TNF‐α) causes a myosin light chain kinase (MLCK)‐‐mediated barrier regulation by inducing occludin removal from the tight junction through caveolar endocytosis. In contrast, MLCK‐ and CK2‐inhibition‐‐caused tight junction regulation is mediated by altered zonula occludens (ZO)‐1 protein dynamics and requires ZO‐1‐‐mediated protein–protein interaction, potentially through regulating claudin function. Although some of the molecular details are missing, studies summarized above point to modulating protein localization and dynamics that are common mechanisms for tight junction regulation.
Related Links	http://europepmc.org/articles/pmc3690943?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690943/pdf https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2012.06613.x
e-ISSN	17496632
DOI	10.1111/j.1749-6632.2012.06613.x
Journal	Annals of the New York Academy of Sciences
Issue Number	1
Volume Number	1258
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-06-25
Access Restriction	Open
Subject Keyword	Journal: Annals of the New York Academy of Sciences Tight Junction Protein Dynamics Fluorescent Recovery After Photobleaching Epithelial Barrier Function
Content Type	Text
Resource Type	Article

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