NDLI: Acute stress and hippocampal output: exploring dorsal CA1 and subicular synaptic plasticity simultaneously in anesthetized rats

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Acute stress and hippocampal output: exploring dorsal CA1 and subicular synaptic plasticity simultaneously in anesthetized rats

Content Provider	Scilit
Author	Dougall, Matthew J. Mac Howland, John G.
Copyright Year	2013
Description	Journal: Physiological reports The Cornu Ammonis-1 (CA1) subfield and subiculum (SUB) serve as major output structures of the hippocampal formation. Exploring forms of synaptic plasticity simultaneously within these two output regions may improve understanding of the dynamics of hippocampal circuitry and information transfer between hippocampal and cortical brain regions. Using a novel dual-channel electrophysiological preparation in urethane-anesthetized adult male Sprague-Dawley rats in vivo, we examined the effects of acute restraint stress (30 min) on short- and long-term forms of synaptic plasticity in both CA1 and SUB by stimulating the CA3 region. Paired-pulse facilitation was disrupted in SUB but not CA1 in the dual-channel experiments following exposure to acute stress. Disruptions in CA1 PPF were evident in subsequent single-channel experiments with a more anterior recording site. Acute stress disrupted long-term potentiation induced by high-frequency stimulation (10 bursts of 20 pulses at 200 Hz) in both CA1 and SUB. Low-frequency stimulation (900 pulses at 1 Hz) did not alter CA1 plasticity while a late-developing potentiation was evident in SUB that was disrupted following exposure to acute stress. These findings highlight differences in the sensitivity to acute stress for distinct forms of synaptic plasticity within synapses in hippocampal output regions. The findings are discussed in relation to normal and aberrant forms of hippocampal-cortical information processing.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831929/pdf
e-ISSN	2051817X
DOI	10.1002/phy2.35
Journal	Physiological reports
Issue Number	2
Volume Number	1
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-07-21
Access Restriction	Open
Subject Keyword	Journal: Physiological reports in Vivo Electrophysiology Late-developing Potentiation Long-term Potentiation Paired-pulse Facilitation
Content Type	Text
Resource Type	Article

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