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High prevalence of willingness to use direct-acting antiviral-based regimens for hepatitis C virus (HCV) infection among HIV/HCV coinfected people who use drugs
| Content Provider | Scilit |
|---|---|
| Author | Socías, Me Ti, L. Dong, H. Shoveller, J. Kerr, T. Montaner, J. Milloy, M-J |
| Copyright Year | 2017 |
| Description | Journal: HIV Medicine Despite the high burden of hepatitis C virus (HCV)-related morbidity and mortality among HIV-positive people who use illicit drugs (PWUD), uptake of interferon-based treatments for HCV infection has been negligible among this group. Direct-acting antiviral (DAA) therapies offer an opportunity to expand treatment access among this population. The aim of this study was to explore willingness to use DAA-based regimens among HIV/HCV-coinfected PWUD in Vancouver, Canada. Data were drawn from the AIDS Care Cohort to evaluate Exposure to Survival Services (ACCESS), a prospective cohort of HIV-positive PWUD. Using logistic regression analyses, we investigated factors associated with willingness to use DAA-based regimens among HIV/HCV-coinfected participants. Of 418 HIV/HCV-coinfected PWUD surveyed between June 2014 and May 2015, 295 (71%) were willing to use DAA-based regimens. In multivariable analysis, participants enrolled in methadone maintenance therapy [adjusted odds ratio (AOR) 1.61; 95% confidence interval (CI) 1.04-2.51], those with a recent assessment by an HCV specialist (AOR 2.02; 95% CI 1.28-3.19) and those who perceived that HCV infection was affecting their health (AOR 2.49; 95% CI 1.41-4.37) were more likely to be willing to use DAA-based regimens. Overall, this study found a high prevalence of willingness to use DAA-based regimens among HIV/HCV-coinfected PWUD in Vancouver. Importantly, enrolment in methadone maintenance therapy was positively associated with willingness, suggesting that integrated models of HIV, HCV and addiction care should be explored as a way to address HCV-related morbidity and mortality among HIV/HCV-coinfected PWUD. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819997/pdf |
| Ending Page | 654 |
| Page Count | 8 |
| Starting Page | 647 |
| e-ISSN | 14681293 |
| DOI | 10.1111/hiv.12501 |
| Journal | HIV Medicine |
| Issue Number | 9 |
| Volume Number | 18 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-03-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: HIV Medicine Substance Abuse Direct-acting Antiviral Agents Hepatitis C Methadone Maintenance Therapy People Who Use Drugs |
| Content Type | Text |
| Resource Type | Article |
