NDLI: Cytotoxic and antiviral activities of Colombian medicinal plant extracts of the Euphorbia genus.

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Cytotoxic and antiviral activities of Colombian medicinal plant extracts of the Euphorbia genus.

Content Provider	Scilit
Author	Betancur-Galvis, L. A. Morales, G. E. Forero, J. E. Roldan, J.
Copyright Year	2002
Description	Forty-seven plant extracts of 10 species of the genus Euphorbia (Euphorbiaceae) used by Colombian traditional healers for the treatment of ulcers, cancers, tumors, warts, and other diseases, were tested in vitro for their potential antitumour (antiproliferative and cytotoxic) and antiherpetic activity. To evaluate the capacity of the extracts to inhibit the lytic activity of herpes simplex virus type 2 (HSV-2) and the reduction of viability of infected or uninfected cell cultures, the end-point titration technique (EPTT) and the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] colorimetric assay were used, respectively. The therapeutic index of the positive extracts for the antiviral activity was determined by calculating the ratio CC50 (50% cytotoxic concentration) over IC50 (50% inhibitory concentration of the viral effect). Five of the 47 extracts (11%) representing 3 out of 10 Euphorbia species (30%) exhibited antiherpetic action; the highest activity was found in the leaf/stem water-methanol extracts from E. cotinifolia and E. tirucalli. The therapeutic indexes of these two plant species were > 7.1; these extracts exhibited no cytotoxicity. Six extracts (13%) representing 4 plant species (40%) showed cytotoxic activity. The highest cytotoxicity was found in the dichloromethane extract obtained from E. cotinifolia leaves and the CC50 values for the most susceptible cell lines, HEp-2 and CHO, were 35.1 and 18.1 microgram/ml, respectively.
Related Links	http://www.scielo.br/pdf/mioc/v97n4/4365.pdf
Ending Page	546
Page Count	6
Starting Page	541
ISSN	00740276
e-ISSN	16788060
DOI	10.1590/s0074-02762002000400017
Journal	Memorias do Instituto Oswaldo Cruz
Issue Number	4
Volume Number	97
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2002-06-01
Access Restriction	Open
Subject Keyword	Memorias do Instituto Oswaldo Cruz Integrative and Complementary Medicine Herpes Simplex Virus
Content Type	Text
Resource Type	Article
Subject	Microbiology (medical)

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