NDLI: Expression analysis of miRNA and target mRNAs in esophageal cancer

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Expression analysis of miRNA and target mRNAs in esophageal cancer

Content Provider	Scilit
Author	Meng, X. R. Lu, P. Mei, J. Z. Liu, G. J. Fan, Q. X.
Copyright Year	2014
Description	We aimed to investigate miRNAs and related mRNAs through a network-based approach in order to learn the crucial role that they play in the biological processes of esophageal cancer. Esophageal squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC)-related miRNA and gene expression data were downloaded from the Gene Expression Omnibus database, and differentially expressed miRNAs and genes were selected. Target genes of differentially expressed miRNAs were predicted and their regulatory networks were constructed. Differentially expressed miRNA analysis selected four miRNAs associated with EAC and ESCC, among which hsa-miR-21 and hsa-miR-202 were shared by both diseases. hsa-miR-202 was reported for the first time to be associated with esophageal cancer in the present study. Differentially expressed miRNA target genes were mainly involved in cancer-related and signal-transduction pathways. Functional categories of these target genes were related to transcriptional regulation. The results may indicate potential target miRNAs and genes for future investigations of esophageal cancer.
Related Links	http://www.scielo.br/pdf/bjmbr/v47n9/1414-431X-bjmbr-1414-431X20143906.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143210/pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-879X2014000900811&lng=en&nrm=iso&tlng=en
Ending Page	817
Page Count	7
Starting Page	811
ISSN	0100879X
e-ISSN	1414431X
DOI	10.1590/1414-431x20143906
Journal	Brazilian Journal of Medical and Biological Research
Issue Number	9
Volume Number	47
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2014-08-01
Access Restriction	Open
Subject Keyword	Brazilian Journal of Medical and Biological Research Gastroenterology and Hepatology Esophageal Adenocarcinoma cell Carcinoma Mirna Expression Network Gene Ontology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Cell Biology Physiology Medicine Biochemistry Biophysics Immunology Pharmacology, Toxicology and Pharmaceutics

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