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Sobre o uso de métodos quimiométricos em química combinatória
| Content Provider | Scilit |
|---|---|
| Author | Leitão, Andrei Montanari, Carlos A. Donnici, Claudio L. |
| Copyright Year | 2000 |
| Description | Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synthesis leads to high throughput screening en masse towards another myriad of biological targets. The design of a set of compounds based upon combinatorial chemistry may be envisaged by using of QSPR-SIMCA and QSAR-SIMCA as tools for classification purposes. This work deals with the definition and establishment of a spanned substituent space (SSS) that reduces the analogue numbers with no exclusion of global content. The chemical diversity may be set properly within a specified pharmacological field. This allows a better use of its potentiality without loosing information |
| Related Links | http://www.scielo.br/pdf/qn/v23n2/2116.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40422000000200007&lng=pt&nrm=iso&tlng=pt |
| Ending Page | 184 |
| Page Count | 7 |
| Starting Page | 178 |
| ISSN | 01004042 |
| e-ISSN | 01004042 |
| DOI | 10.1590/s0100-40422000000200007 |
| Journal | Química Nova |
| Issue Number | 2 |
| Volume Number | 23 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2000-04-01 |
| Access Restriction | Open |
| Subject Keyword | Química Nova Combinatorial Chemistry Chemical Diversity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
