NDLI: Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs

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Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs

Content Provider	Scilit
Author	Takahashi, Andrea Ikeda Lourenço, Felipe Rebello Duque, Marcelo Dutra Consiglieri, Vladi Olga Ferraz, Humberto Gomes
Copyright Year	2012
Description	In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and then compressed into tablets. The dissolution behavior of the tablets was studied by comparing their dissolution profiles and dissolution efficiency with those obtained from physical mixtures of the drug and excipients subjected to similar conditions. Statistical analysis of the results demonstrated that the fluid bed granulation process improves the dissolution efficiency of both nimodipine and spironolactone tablets. The addition of either the surfactant or the disintegrant employed in the study proved to have a lower impact on this improvement in dissolution than the fluid bed granulation process
Related Links	http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1516-89132012000300020&lng=en&nrm=iso&tlng=en
Ending Page	484
Page Count	8
Starting Page	477
ISSN	15168913
e-ISSN	16784324
DOI	10.1590/s1516-89132012000300020
Journal	Brazilian Archives of Biology and Technology
Issue Number	3
Volume Number	55
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2012-06-01
Access Restriction	Open
Subject Keyword	Brazilian Archives of Biology and Technology Pharmacology and Pharmacy Poorly Water Soluble Drugs Fluid Bed Granulation Using Fluid Bed
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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