Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke

Content Provider	Scilit
Author	Protti, Gustavo G. Gagliardi, Rubens J. Forte, Wilma C. N. Sprovieri, Sandra Regina S.
Copyright Year	2013
Description	Atherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent secondary ischemic injury. Objectives 1) To assess the relationship between stroke severity and the serum levels of IL-1β, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins. Method We measured the serum levels of IL-1β, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls. Results Patients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h. Conclusion IL-10 may protect against ischemic injury during the acute phase of stroke.
Related Links	http://www.scielo.br/pdf/anp/v71n11/0004-282X-anp-71-11-0846.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-282X2013001200846&lng=en&nrm=iso&tlng=en
Ending Page	851
Page Count	6
Starting Page	846
ISSN	0004282X
e-ISSN	16784227
DOI	10.1590/0004-282x20130168
Journal	Arquivos de Neuro-Psiquiatria
Issue Number	11
Volume Number	71
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2013-11-01
Access Restriction	Open
Subject Keyword	Psiquiatria Acidente Vascular Cerebral Isquemico
Content Type	Text
Resource Type	Article
Subject	Neurology Biological Psychiatry Neurology (clinical)