NDLI: Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína

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Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína

Content Provider	Scilit
Author	de Melo, Nathalie Ferreira Silva Grillo, Renato Rosa, André Henrique Fraceto, Leonardo Fernandes Filho, Newton Luiz Dias de Paula, Eneida de Araújo, Daniele Ribeiro
Copyright Year	2010
Description	In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment
Related Links	http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40422010000100013&lng=pt&nrm=iso&tlng=pt
Ending Page	69
Page Count	5
Starting Page	65
ISSN	01004042
e-ISSN	01004042
DOI	10.1590/s0100-40422010000100013
Journal	Química Nova
Issue Number	1
Volume Number	33
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2010-01-01
Access Restriction	Open
Subject Keyword	Química Nova Contendo Benzocana Desenvolvimento E Caracterizao Nanocpsulas De Poli
Content Type	Text
Resource Type	Article
Subject	Chemistry

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