NDLI: Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze.

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Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze.

Content Provider	Scilit
Author	Ribas, Valdenilson Ribeiro Aniceto, Helena Karine Rufino Martins, Hugo André De Lima Ribas, Ketlin Helenise Dos Santos Guerra-Ribas, Renata De Melo Fraga, Simone Do Nascimento Ribeiro-Ribas, Valéria Vasconcelos, Célia Maria Mendes Viana, Marcelo Tavares Manhaes-De-Castro, Raul
Copyright Year	2008
Description	The objective of this study was evaluate the anxiety and locomotor activity (LA) in 52 Wistar adult male rats, being 26 treated with fluoxetine (10 mg/Kg - sc) in the neonatal period. These same rats received foot shock (FS) (1.6-mA - 2-s) in the 90th day. The anxiety and LA were appraised by plus-maze. The time spent in the open arms was used as anxiety index and the LA was measured by number of entries in closed arms (NECA) and the total of entries (TE). T-test was used with p<0.05 and expresses data in mean+/-SEM. There were reductions with the fluoxetine group in the NECA (2.35+/-0.33) and in the TE (3.96+/-0.61) compared to the controls (4.65+/-0.52) and (6.96+/-0.94). The neonatal administration of fluoxetine did not alter the anxiety, but reduced the LA in the animals that received FS.
Related Links	http://www.scielo.br/pdf/anp/v66n4/v66n4a13.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-282X2008000600013&lng=en&nrm=iso&tlng=en
Ending Page	847
Page Count	4
Starting Page	844
ISSN	0004282X
e-ISSN	16784227
DOI	10.1590/s0004-282x2008000600013
Journal	Arquivos de Neuro-Psiquiatria
Issue Number	4
Volume Number	66
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2008-12-01
Access Restriction	Open
Subject Keyword	Psiquiatria Behavioral Sciences Administration of Fluoxetine Alter the Anxiety
Content Type	Text
Resource Type	Article
Subject	Neurology Biological Psychiatry Neurology (clinical)

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Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze

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