NDLI: N(4)-tolyl-2-benzoylpyridine thiosemicarbazones and their copper(II) complexes with significant antifungal activity: crystal structure of N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone

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N(4)-tolyl-2-benzoylpyridine thiosemicarbazones and their copper(II) complexes with significant antifungal activity: crystal structure of N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone

Content Provider	Scilit
Author	Mendes, Isolda C. Moreira, Juliana P. Speziali, Nivaldo L. Mangrich, Antonio S. Takahashi, Jacqueline A. Beraldo, Heloisa
Copyright Year	2006
Description	Three new copper complexes of general formula [Cu(HL)Cl2] have been obtained with N(4)-ortho (H2Bz4oT, HL1), N(4)-meta (H2Bz4mT, HL2) and N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone (H2Bz4pT, HL3), in which the thiosemicarbazone attaches to the metal through the Npy-N-S chelating system. H2Bz4pT (HL3) crystallizes in the P1 space group, with a = 9.509(3) Å, b = 9.807(4) Å, c = 11.564(4) Å; alpha = 100.76(2)°, beta = 105.99(2)°, gamma = 114.59(2)°. The thiosemicarbazones and their copper(II) complexes exhibit high antifungal activities against Candida albicans with low values of minimum inhibitory concentration (MIC), in the 8-0.3 µg mL-1 (23 - 0.7 µmol L-1) range for the free bases and in the 1-0.1 µg mL-1 (2 - 0.3 µmol L-1) range for the complexes. Our results suggest that coordination to copper(II) could be an interesting strategy for dose reduction.
Related Links	http://www.scielo.br/pdf/jbchs/v17n8/12.pdf
Ending Page	1577
Page Count	7
Starting Page	1571
ISSN	01035053
e-ISSN	16784790
DOI	10.1590/s0103-50532006000800013
Journal	Journal of the Brazilian Chemical Society
Issue Number	8
Volume Number	17
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2006-12-01
Access Restriction	Open
Subject Keyword	Journal of the Brazilian Chemical Society Thiosemicarbazones Copper(ii) Complexes Antifungal Activity
Content Type	Text
Resource Type	Article
Subject	Chemistry

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