NDLI: Diazepam e nordiazepam em plasma: métodos de extração líquido-líquido e em fase sólida no pré-tratamento de amostras para análise cromatográfica em fase líquida

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Diazepam e nordiazepam em plasma: métodos de extração líquido-líquido e em fase sólida no pré-tratamento de amostras para análise cromatográfica em fase líquida

Content Provider	Scilit
Author	Freire, Ellen Figueiredo Miranda, Juniella Luiza Maia, Patrícia Penido Vieira, Elisabeth Pizzamiglio Borges, Keyller Bastos de Siqueira, Maria Elisa Pereira Bastos
Copyright Year	2005
Description	Analysis of diazepam (DZP) and its active metabolite nordiazepam (NDZP) in plasma is commonly performed in clinical medicine to ensure proper therapeutic effects while minimizing the incidence of toxicity. This study aimed to optimize analytical parameters and compare two pre-treatment techniques, liquid-liquid (LLE) and solid phase extraction (SPE), as well as liquid chromatographic conditions to analyze simultaneously DZP and NDZP in plasma from 20 patients treated with a daily dose of 10 mg. Both techniques showed to be well in line with the international criteria for analytical validation, which permitted to quantify DZP (66.2 - 1148.6 ng mL-1) and NDZP (138.5 - 808.6 ng mL -1) in all samples. The correlation coefficients between SPE and LLE were respectively 0.9729 for DZP and 0.9643 for NDZP
Related Links	http://www.scielo.br/pdf/qn/v28n5/25898.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40422005000500007&lng=pt&nrm=iso&tlng=pt
Ending Page	776
Page Count	4
Starting Page	773
ISSN	01004042
e-ISSN	01004042
DOI	10.1590/s0100-40422005000500007
Journal	Química Nova
Issue Number	5
Volume Number	28
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2005-10-01
Access Restriction	Open
Subject Keyword	Química Nova Nordiazepam Em Em Plasma Em Fase Para Anlise Slida No
Content Type	Text
Resource Type	Article
Subject	Chemistry

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