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A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes
| Content Provider | Scilit |
|---|---|
| Author | Neto, A. B. Hirata, D. B. Filho, L. C. M. Cassiano Bellão, C. Júnior, A. C. Badino Hokka, C. O. |
| Copyright Year | 2005 |
| Description | Clavulanic acid (CA) is a potent inhibitor of beta-lactamases, enzymes that are responsible for the hydrolysis of beta-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasing productivity. The operating conditions: temperature, aeration and agitation, were the same in all cases, 28º C, 0.5 vvm and 800 rpm, respectively. The CA concentration obtained in the fed-batch culture, 404 mg L-1, was ca twice the value obtained in the batch culture, 194 mg L-1, while 293 mg L-1 was obtained in the continuous culture. The highest productivity was obtained in the continuous cultivation, 10.6 mg L-1 h-1, as compared with 8.8 mg L-1 h-1 in the fed-batch process and 3.5 mg L-1 h-1 in the batch process, suggesting that continuous culture of Streptomyces clavuligerus is a promising strategy for clavulanic acid production |
| Related Links | http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0104-66322005000400008&lng=en&nrm=iso&tlng=en |
| Ending Page | 563 |
| Page Count | 7 |
| Starting Page | 557 |
| ISSN | 01046632 |
| e-ISSN | 16784383 |
| DOI | 10.1590/s0104-66322005000400008 |
| Journal | Brazilian Journal of Chemical Engineering |
| Issue Number | 4 |
| Volume Number | 22 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2005-12-01 |
| Access Restriction | Open |
| Subject Keyword | Brazilian Journal of Chemical Engineering Biotechnology and Microbiology Clavulanic Acid |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemical Engineering |
