NDLI: Risk factors for alloimmunization by patients with sickle cell disease

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Risk factors for alloimmunization by patients with sickle cell disease

Content Provider	Scilit
Author	Murao, M. Viana, M. B.
Copyright Year	2005
Description	Blood transfusion in patients with sickle cell disease (SCD) is limited by the development of alloantibodies to erythrocytes. In the present study, the frequency and risk factors for alloimmunization were determined. Transfusion records and medical charts of 828 SCD patients who had been transfused and followed at the Belo Horizonte Blood Center, Belo Horizonte, MG, Brazil, were retrospectively reviewed. Alloimmunization frequency was 9.9% (95% CI: 7.9 to 11.9%) and 125 alloantibodies were detected, 79% of which belonged to the Rhesus and Kell systems. Female patients developed alloimmunization more frequently (P = 0.03). The median age of the alloimmunized group was 23.3 years, compared to 14.6 years for the non-alloimmunized group (P < 0.0001). Multivariate analyses were applied to the data for 608 hemoglobin (Hb) SS or SC patients whose number of transfusions was recorded accurately. Number of transfusions (P = 0.00006), older age (P = 0.056) and Hb SC (P = 0.02) showed independent statistical associations with alloimmunization. Hb SC patients older than 14 years faced a 2.8-fold higher (95% CI: 1.3 to 6.0) risk of alloimmunization than Hb SS patients. Female Hb SC patients had the highest risk of developing alloantibodies. In patients younger than 14 years, only the number of transfusions was significant. We conclude that an increased risk of alloimmunization was associated with older patients with Hb SC, specially females, even after adjustments were made for the number of transfusions received, the most significant variable.
Related Links	http://www.scielo.br/pdf/bjmbr/v38n5/5409.pdf
Ending Page	682
Page Count	8
Starting Page	675
ISSN	0100879X
e-ISSN	1414431X
DOI	10.1590/s0100-879x2005000500004
Journal	Brazilian Journal of Medical and Biological Research
Issue Number	5
Volume Number	38
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2005-05-01
Access Restriction	Open
Subject Keyword	Brazilian Journal of Medical and Biological Research Sickle Cell Disease Red Cell Alloimmunization Blood Cell Transfusion Transfusion Reactions
Content Type	Text
Resource Type	Article
Subject	Neuroscience Cell Biology Physiology Medicine Biochemistry Biophysics Immunology Pharmacology, Toxicology and Pharmaceutics

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