NDLI: Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

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Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

Content Provider	Scilit
Author	Vaz, Márcia Krebs, Rodrigo Ketzer Trindade, Eduardo Neubarth Trindade, Manoel Roberto Maciel
Copyright Year	2009
Description	PURPOSE: This study assessed the collagen deposition and correlated it with local inflammatory responses to evaluate the length of time required for fibroplasia when polypropylene meshes are used to repair incisional abdominal wall hernias in rats. METHODS: Thirty-six male Wistar rats underwent longitudinal resection of a peritoneal and musculoaponeurotic tissue segment (3x2 cm) of the abdominal wall followed by defect reconstruction with polypropylene mesh bridging over aponeurosis. The animals were divided into 6 groups according to the time points for the analysis of fibroplasia: 1, 2, 3, 7, 21 and 30 days post-implantation. Animals were sacrificed at each time point, and the site where the polypropylene mesh was implanted was evaluated histologically to assess inflammatory response and percentage of collagen using computer-assisted videomorphometry. RESULTS: Total collagen was found at the mesh site on the 3rd day post-implantation, and increased progressively on all subsequent days up to the 21st day, when it reached its highest percentage (p0.001). Type I collagen was first found between the 7th and 21st days; it reached its highest percentage on the 21st day and then remained stable until the 30th day. The type I to type III collagen ratio increased significantly and progressively up to the 30th day (p
Related Links	http://www.scielo.br/pdf/acb/v24n1/v24n1a05.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0102-86502009000100005&lng=en&nrm=iso&tlng=en
Ending Page	25
Page Count	7
Starting Page	19
ISSN	01028650
e-ISSN	16782674
DOI	10.1590/s0102-86502009000100005
Journal	Acta Cirurgica Brasileira
Issue Number	1
Volume Number	24
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2009-02-01
Access Restriction	Open
Subject Keyword	Acta Cirurgica Brasileira Pediatrics and Child Health Abdominal Wall Hernia Fibroplasia After Polypropylene Mesh
Content Type	Text
Resource Type	Article
Subject	Surgery

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