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Cholinergic stimulation with pyridostigmine, hemodynamic and echocardiographic analysis in healthy subjects
| Content Provider | Scilit |
|---|---|
| Author | de Pontes, Paulo Vasconcellos Bastos, Bianca Gouveia F°, Luiz José Martins Romêo Mesquita, Evandro Tinoco Nóbrega, Antonio Claudio Lucas da |
| Copyright Year | 1999 |
| Description | OBJECTIVE: Growing evidence suggests that sudden death after an acute myocardial infarction (AMI) correlates with autonomic nervous system imbalance. Parasympathomimetic drugs have been tested to reverse these changes. However, their effects on ventricular function need specific evaluation. Our objective was to analyze pyridostigmine's (PYR) effect on hemodynamic and echocardiographic variables of ventricular function. METHODS: Twenty healthy volunteers underwent Doppler echocardiographic evaluations, blood pressure (BP), and heart rate (HR) assessment at rest, before and 120 min after ingestion of 30 mg PYR or placebo, according to a double-blind, placebo-controlled, crossed and randomized protocol, on different days. RESULTS: PYR was well tolerated and did not cause alterations in BP or in ventricular systolic function. A reduction in HR of 10.9±1.3% occurred (p0.05). CONCLUSION: PYR reduces HR and increases E/A ratio, without hemodynamic impairment or ventricular function change |
| Related Links | http://www.scielo.br/pdf/abc/v72n3/a03v72n3.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0066-782X1999000300003&lng=en&nrm=iso&tlng=en |
| Ending Page | 306 |
| Page Count | 10 |
| Starting Page | 297 |
| ISSN | 0066782X |
| e-ISSN | 16784170 |
| DOI | 10.1590/s0066-782x1999000300003 |
| Journal | Arquivos Brasileiros de Cardiologia |
| Issue Number | 3 |
| Volume Number | 72 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 1999-03-01 |
| Access Restriction | Open |
| Subject Keyword | Arquivos Brasileiros de Cardiologia Echocardiographic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |