Loading...
Please wait, while we are loading the content...
Similar Documents
Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population
| Content Provider | Scilit |
|---|---|
| Author | Alami, Faranak Mahmoudi Ahmadi, Mehran Bazrafshan, Hamidreza Tabarraei, Alijan Khosravi, Ayyoob Tabatabaiefar, Mohammad Amin Samaei, Nader Mansour |
| Copyright Year | 2012 |
| Description | In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108–1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147–3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05–2.21) p = 0.026)] and 1.74 [95% CI (1.01–3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM. |
| Related Links | http://www.scielo.br/pdf/gmb/v35n2/2011-301.pdf https://core.ac.uk/download/pdf/52204744.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389527/pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1415-47572012000300005&lng=en&nrm=iso&tlng=en |
| Ending Page | 417 |
| Page Count | 5 |
| Starting Page | 413 |
| ISSN | 14154757 |
| e-ISSN | 16784685 |
| DOI | 10.1590/s1415-47572012005000029 |
| Journal | Genetics and Molecular Biology |
| Issue Number | 2 |
| Volume Number | 35 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2012-05-17 |
| Access Restriction | Open |
| Subject Keyword | Genetics and Molecular Biology Medical Laboratory Technology Tcf7l2 Gene Rs12255372 Variant Type 2 Diabetes Mellitus (t2dm) Single Nucleotide Polymorphism (snp) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology |
