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Desenvolvimento e validação de um método analítico rápido por cromatografia líquida de alta eficiência para determinação de nimesulida em estudos de liberação in vitro
| Content Provider | Scilit |
|---|---|
| Author | Ruela, André Luís Morais Araújo, Magali Benjamim Pereira, Gislaine Ribeiro |
| Copyright Year | 2009 |
| Description | A high performance liquid chromatography (HPLC) method has been developed for a rapid determination of nimesulide in dissolution studies. Nimesulide was analyzed using 5 µm Lichrospher® RP-18 column (125 x 4 mm i.d.) and mobile phase acetonitrile: phosphate buffer pH=6.0 (55:45) at a flow-rate of 1.0 mL min-1. Detection was carried out at 300 nm at 25 ºC. The method was applied to analysis of nimesulide in in vitro release studies and showed a rapid and efficient analytical alternative for evaluation of dissolution profile of nimesulide |
| Related Links | http://www.scielo.br/pdf/qn/v32n1/v32n1a31.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40422009000100031&lng=pt&nrm=iso&tlng=pt |
| Ending Page | 168 |
| Page Count | 4 |
| Starting Page | 165 |
| ISSN | 01004042 |
| e-ISSN | 01004042 |
| DOI | 10.1590/s0100-40422009000100031 |
| Journal | Química Nova |
| Issue Number | 1 |
| Volume Number | 32 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2009-01-01 |
| Access Restriction | Open |
| Subject Keyword | Química Nova Por Cromatografia Cromatografia Lquida |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
