NDLI: Safety and skin delayed-type hypersensitivity response in vervet monkeys immunized with Leishmania donovani sonicate antigen delivered with adjuvants.

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Safety and skin delayed-type hypersensitivity response in vervet monkeys immunized with Leishmania donovani sonicate antigen delivered with adjuvants.

Content Provider	Scilit
Author	Mutiso, Joshua M. Macharia, John C. Taracha, Evans Wafula, Kellern Rikoi, Hitler Gicheru, Michael M.
Copyright Year	2012
Description	In this study, we report on the safety and skin delayed-type hypersensitivity (DTH), responses of the Leishmania donovani whole cell sonicate antigen delivered in conjunction with alum-BCG (AlBCG), Montanide ISA 720 (MISA) or Monophosphoryl lipid A (MPLA) in groups of vervet monkeys. Following three intradermal injections of the inoculums on days 0, 28 and 42, safety and DTH responses were assessed. Preliminary tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) levels were also measured and these were compared with DTH. Only those animals immunized with alum-BCG reacted adversely to the inoculum by producing ulcerative erythematous skin indurations. Non-parametric analysis of variance followed by a post-test showed significantly higher DTH responses in the MISA+Ag group compared with other immunized groups (p < 0.001). The MPLA+Ag group indicated significantly lower DTH responses to the sonicate antigen compared with the AlBCG+Ag group. There was a significant correlation between the DTH and cytokine responses (p < 0.0001). Based on this study we conclude that Leishmania donovani sonicate antigen containing MISA 720 is safe and is associated with a strong DTH reaction following immunization.
Related Links	http://www.scielo.br/pdf/rimtsp/v54n1/a07v54n1.pdf
Ending Page	41
Page Count	5
Starting Page	37
e-ISSN	16789946
DOI	10.1590/s0036-46652012000100007
Journal	Revista Do Instituto de Medicina Tropical de São Paulo
Issue Number	1
Volume Number	54
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2012-02-01
Access Restriction	Open
Subject Keyword	Revista Do Instituto de Medicina Tropical de São Paulo Veterinary Sciences type Hypersensitivity (dth) Vervet Monkeys Leishmania Donovani Sonicate Antigen
Content Type	Text
Resource Type	Article

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