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Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada
| Content Provider | Scilit |
|---|---|
| Author | Cordeiro, Gilcélia A. Peralta-Zamora, Patricio Nagata, Noemi Pontarollo, Roberto |
| Copyright Year | 2008 |
| Description | In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives |
| Related Links | http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40422008000200012&lng=pt&nrm=iso&tlng=pt |
| Ending Page | 260 |
| Page Count | 7 |
| Starting Page | 254 |
| ISSN | 01004042 |
| e-ISSN | 01004042 |
| DOI | 10.1590/s0100-40422008000200012 |
| Journal | Química Nova |
| Issue Number | 2 |
| Volume Number | 31 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Subject Keyword | Química Nova Por Espectroscopia Espectroscopia Eletrnica Eletrnica Multivariada |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
