NDLI: Inibidores seletivos de prostaglandina endoperóxido sintase-2 (PGHS-2): nova estratégia para o tratamento da inflamação

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Inibidores seletivos de prostaglandina endoperóxido sintase-2 (PGHS-2): nova estratégia para o tratamento da inflamação

Content Provider	Scilit
Author	Lages, Adriana dos Santos Romeiro, Nelilma Correia Fraga, Carlos Alberto Manssour Barreiro, Eliezer Jesus
Copyright Year	1998
Description	Prostaglandins (PG's), produced from arachidonic acid metabolism, are potent mediators of inflammation. Nonsteroidal anti-inflammatory (NSAIDs) exert their effects by inhibition of prostaglandin endoperoxide synthase (PGHS) enzyme, which catalyses the first committed step in arachidonic acid metabolism. Two isoforms of PGHS are known: PGHS-1, constitutively expressed in most tissues, and is responsible for physiological production of PG's. The second isoform, PGHS-2, is induced by cytokines, mitogens and endotoxins in inflammatory cells, and appears to be responsible for the elevated production of PG's during inflammation. With the recent discovery of the inducible PGHS (PGHS-2), the medicinal chemist now possesses a novel target for designing therapeutic agents that could provide suitable anti-inflammatory activity without the ulcerogenic and renal side effects associated with currently available NSAIDs, all of which inhibit both PGHS-1 and PGHS-2
Related Links	http://www.scielo.br/pdf/qn/v21n6/2911.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40421998000600017&lng=pt&nrm=iso&tlng=pt
Ending Page	771
Page Count	11
Starting Page	761
ISSN	01004042
e-ISSN	01004042
DOI	10.1590/s0100-40421998000600017
Journal	Química Nova
Issue Number	6
Volume Number	21
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	1998-11-01
Access Restriction	Open
Subject Keyword	Química Nova Integrative and Complementary Medicine Da Inflamao Inibidores Seletivos Nova Estratgia Tratamento Da Prostaglandina Endoperxido Endoperxido Sintase Estratgia Para
Content Type	Text
Resource Type	Article
Subject	Chemistry

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