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RETREATMENT WITH SURFACTANT IN VERY LOW BIRTH WEIGHT PRETERM INFANTS: RISK PREDICTORS AND THEIR INFLUENCE ON NEONATAL OUTCOMES
| Content Provider | Scilit |
|---|---|
| Author | Ferri, Walusa Assad Gonçalves Silva, Adriana Carnevale da Sacramento, Eliana Motta Fernandes Calixto, Cristina Aragon, Davi Casale Caldas, Jamil Pedro De Siqueira |
| Copyright Year | 2021 |
| Description | Objective: To assess clinical predictors and outcomes associated to the need for surfactant retreatment in preterm infants. Methods: Retrospective cohort study, including very low birth weight preterm infants from January 2006 to December 2015 who underwent surfactant replacement therapy. Beractant was used (100 mg/kg), repeated every six hours if FiO2 ≥0.40. The subjects were classified into two groups: single surfactant dose; and more than one dose (retreatment). We evaluated maternal and neonatal predictors for the need of retreatment and neonatal outcomes associated to retreatment. Results: A total of 605 patients (44.5%) received surfactant; 410 (67.8%) one dose, and 195 (32.2%) more than one dose: 163 (83.5%) two doses and 32 (16.4%) three doses. We could not find clinical predictors for surfactant retreatment. Retreatment was associated to a greater chance of BPD in infants >1000 g (RR 1.78; 95%CI 1.30‒2.45) and ≤1000 g (RR 1.33; 95%CI 1.04‒1.70), in infants with gestational age<28 weeks (RR 1.56; 95%CI 1.12‒2.18) and ≥28 weeks (RR 1.50; 95%CI 1.17‒1.92), in neonates with early sepsis (RR 1.48; 95%CI 1.20‒1.81), and in infants not exposed to antenatal corticosteroids (RR 1.62; 95%CI 1.20‒2.17) Conclusions: We could not find predictor factors associated to surfactant retreatment. The need for two or more doses of surfactant was significantly related to bronchopulmonary dysplasia. |
| Related Links | http://www.scielo.br/pdf/rpp/v39/1984-0462-rpp-39-e2019360.pdf |
| ISSN | 01030582 |
| e-ISSN | 19840462 |
| DOI | 10.1590/1984-0462/2021/39/2019360 |
| Journal | Revista Paulista de Pediatria |
| Volume Number | 39 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Revista Paulista de Pediatria Pediatrics and Child Health Pulmonary Surfactant Risk Factors Preterm Infant Bronchopulmonary Dysplasia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
