NDLI: Ferumoxytol-Enhanced Magnetic Resonance Imaging in Late-Stage CKD

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Ferumoxytol-Enhanced Magnetic Resonance Imaging in Late-Stage CKD

Content Provider	Scilit
Author	Mukundan, Srinivasan Steigner, Michael L. Hsiao, Li-Li Malek, Sayeed K. Tullius, Stefan G. Chin, Matthew S. Siedlecki, Andrew M.
Copyright Year	2016
Description	Journal: American Journal of Kidney Diseases Ferumoxytol is a superparamagnetic iron oxide particle encapsulated by a semisynthetic carbohydrate with properties that can be used by the nephrologist for diagnosis and therapy. Ferumoxytol is approved by the US Food and Drug Administration for treating iron deficiency anemia in the setting of chronic kidney disease, but not for clinical diagnostic imaging. It has gained appeal as a magnetic resonance imaging contrast agent in patients with estimated glomerular filtration rates < $30mL/min/1.73m^{2}$ in whom gadolinium-based contrast magnetic resonance imaging agents are relatively contraindicated because of the association with gadolinium deposition and nephrogenic systemic fibrosis. Ferumoxytol metabolism is not dependent on kidney function, but rather is removed from the circulation by the reticuloendothelial system of the liver, spleen, and bone marrow. Additionally, the prolonged intravascular half-life (>14 hours) of ferumoxytol allows for longer image acquisition and repeat imaging, if necessary. In patients with contraindications for gadolinium contrast agents, ferumoxytol is an alternative agent for vascular assessment, including patency and course.
Related Links	http://europepmc.org/articles/pmc4877283?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877283/pdf http://www.ajkd.org/article/S0272638615014985/pdf
Ending Page	988
Page Count	5
Starting Page	984
ISSN	02726386
e-ISSN	15236838
DOI	10.1053/j.ajkd.2015.12.017
Journal	American Journal of Kidney Diseases
Issue Number	6
Volume Number	67
Language	English
Publisher	Elsevier BV
Publisher Date	2016-06-01
Access Restriction	Open
Subject Keyword	Journal: American Journal of Kidney Diseases Urology and Nephrology Renal Failure Chronic Kidney Disease (ckd) Magnetic Resonance Imaging (mri) Magnetic Resonance Angiography (mra) Ultra-small Superparamagnetic Iron Oxide (uspio) Contrast Agent
Content Type	Text
Resource Type	Article
Subject	Nephrology

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