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Analytical challenges of shotgun lipidomics at different resolution of measurements
| Content Provider | Scilit |
|---|---|
| Author | Wang, Jianing Han, Xianlin |
| Copyright Year | 2019 |
| Description | Journal: Trac Trends in Analytical Chemistry The essence of shotgun lipidomics is to maintain consistency of the chemical environment of lipid samples during mass spectrometry acquisition. This strategy is suitable for large-scale quantitative analysis. This strategy also allows sufficient time to collect data to improve the signal-to-noise ratio. The initial approach of shotgun lipidomics was the electrospray ionization (ESI)-based direct infusion mass spectrometry strategy. With development of mass spectrometry for small molecules, shotgun lipidomics methods have been extended to matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) and ambient mass spectrometry, including MS imaging methods. Furthermore, the object of analysis has extended from organ and body fluid levels to tissue and cell levels with technological developments. In this article, we summarize the status and technical challenges of shotgun lipidomics at different resolution of measurements from the mass spectrometry perspective. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382544/pdf |
| ISSN | 01659936 |
| DOI | 10.1016/j.trac.2019.115697 |
| Journal | Trac Trends in Analytical Chemistry |
| Volume Number | 121 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-10-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Trac Trends in Analytical Chemistry Analytical Chemistry High Resolution Mass Spectrometry Mass Spectrometry Imaging Single-cell Analysis Shotgun Lipidomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry |
