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Multisource Rotating Shield Brachytherapy Apparatus for Prostate Cancer
| Content Provider | Scilit |
|---|---|
| Author | Dadkhah, Hossein Hopfensperger, Karolyn M. Kim, Yusung Wu, Xiaodong Flynn, Ryan T. |
| Copyright Year | 2017 |
| Description | Journal: International Journal of Radiation Oncology - Biology - Physics Purpose Our purpose is to present a novel multisource rotating shield brachytherapy (RSBT) apparatus for the simultaneous precise angular and linear positioning of partially shielded$ ^{153}$Gd brachytherapy sources in interstitial needles for the treatment of locally advanced prostate cancer. It is designed to lower the dose to nearby healthy tissues, the urethra in particular, relative to conventional high-dose-rate brachytherapy techniques. Methods and Materials Following needle implantation through the patient template, an angular drive mechanism is docked to the patient template. Each needle is coupled to a multisource afterloader catheter by a connector passing through a shaft. The shafts are rotated about their axes by translating a moving template between 2 stationary templates. The shafts' surfaces and moving template holes are helically threaded with the same pattern such that translation of the moving template causes simultaneous rotation of the shafts. The rotation of each shaft is mechanically transmitted to the catheter-source-shield combination, inside the needles, via several key-keyway pairs. The catheter angles are simultaneously incremented throughout treatment, and only a single 360° rotation of all catheters is needed for a full treatment. For each rotation angle, source depth in each needle is controlled by a multisource afterloader, which is proposed as an array of belt-driven linear actuators, each of which drives a wire that controls catheter depth in a needle. Results Treatment plans demonstrated that RSBT with the proposed apparatus reduced urethral D_{0.1cm^{3}$}$ (the minimum dose delivered to the hottest $0.1cm^{3}$ of the urethra) below that of conventional high-dose-rate brachytherapy by 31% for urethral dose gradient volume within 3 mm of the urethra surface. Treatment time to deliver 20 Gy with the proposed multisource RSBT apparatus by use of nineteen 62.4-GBq$ ^{153}$Gd sources was 122 minutes. Conclusions The proposed RSBT delivery apparatus enables a mechanically feasible urethra-sparing treatment technique for prostate cancer in a clinically reasonable time frame. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738279/pdf http://www.redjournal.org/article/S036030161731057X/pdf |
| Ending Page | 728 |
| Page Count | 10 |
| Starting Page | 719 |
| ISSN | 03603016 |
| DOI | 10.1016/j.ijrobp.2017.06.008 |
| Journal | International Journal of Radiation Oncology - Biology - Physics |
| Issue Number | 3 |
| Volume Number | 99 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-06-20 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Radiation Oncology - Biology - Physics Urology and Nephrology Dose Rate Conventional High Rate Brachytherapy Multisource Afterloader |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Cancer Research Radiation Oncology |
