NDLI: BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management

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BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management

Content Provider	Scilit
Author	Limpose, Kristin L. Corbett, Anita H. Doetsch, Paul W.
Copyright Year	2017
Description	Journal: DNA repair DNA base damage and non-coding apurinic/apyrimidinic (AP) sites are ubiquitous types of damage that must be efficiently repaired to prevent mutations. These damages can occur in both the nuclear and mitochondrial genomes. Base excision repair (BER) is the frontline pathway for identifying and excising damaged DNA bases in both of these cellular compartments. Recent advances demonstrate that BER does not operate as an isolated pathway but rather dynamically interacts with components of other DNA repair pathways to modulate and coordinate BER functions. We define the coordination and interaction between DNA repair pathways as pathway crosstalk. Numerous BER proteins are modified and regulated by post-translational modifications (PTMs), and PTMs could influence pathway crosstalk. Here, we present recent advances on BER/DNA repair pathway crosstalk describing specific examples and also highlight regulation of BER components through PTMs. We have organized and reported functional interactions and documented PTMs for BER proteins into a consolidated summary table. We further propose the concept of DNA repair hubs that coordinate DNA repair pathway crosstalk to identify central protein targets that could play a role in designing future drug targets.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576989/pdf
Ending Page	64
Page Count	14
Starting Page	51
ISSN	15687864
e-ISSN	15687856
DOI	10.1016/j.dnarep.2017.06.007
Journal	DNA repair
Volume Number	56
Language	English
Publisher	Elsevier BV
Publisher Date	2017-08-01
Access Restriction	Open
Subject Keyword	Journal: DNA repair Biochemistry and Molecular Biology Base Excision Repair Ber Dna Damage Dna Pathway Crosstalk Dna Repair Hubs Post-translational Modifications Ptms
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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