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CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of triple negative breast cancer
| Content Provider | Scilit |
|---|---|
| Author | Wang, Zhaoxian Sau, Samaresh Alsaab, Hashem O. Iyer, Arun K. |
| Copyright Year | 2018 |
| Description | Journal: Nanomedicine: Nanotechnology, Biology and Medicine Triple negative breast cancer (TNBC) is a highly aggressive tumor subtype, lacking estrogen, progesterone and human epidermal growth factor-2 (HER-2) receptors. Thus, early detection and targeted therapy of TNBC is an urgent need. Herein, we have developed a CD44 targeting Hyaluronic Acid (HA) decorated biocompatible oligomer, containing FDA approved vitamin E TPGS and Styrene Maleic Anhydride (SMA) (HA-SMA-TPGS) for targeting TNBC. The self-assembling HA-SMA-TPGS was encapsulated with poorly water soluble, potent curcumin analogue (CDF) to form nanomicelles (NM), HA-SMA-TPGS-CDF has demonstrated excellent nanoparticle charateristics for parenteral delivery. The targeted NM can selectively kill TNBC cells through CD44 mediated apoptosis pathway. Tumor imaging using phase-2 clinical trial near infrared (NIR)-fluorescent dye (S0456) conjugate, HA-SMA-TPGS-S0456 showed excellent TNBC tumor accumulation with minimum liver and spleen uptake. To our best of knowledge, for the first time, we are reporting a promising platform for CD44 mediated multimodal NIR imaging and cytotoxin delivery to TNBC. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192858/pdf http://www.nanomedjournal.com/article/S1549963418300765/pdf |
| Ending Page | 1454 |
| Page Count | 14 |
| Starting Page | 1441 |
| ISSN | 15499634 |
| e-ISSN | 15499642 |
| DOI | 10.1016/j.nano.2018.04.004 |
| Journal | Nanomedicine: Nanotechnology, Biology and Medicine |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Nanomedicine: Nanotechnology, Biology and Medicine Triple Negative Breast Cancer Fluorescence Imaging of Tnbc |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Molecular Medicine Bioengineering Biomedical Engineering Pharmaceutical Science |
