NDLI: Spray drying of poorly soluble drugs from aqueous arginine solution

Please wait, while we are loading the content...

Spray drying of poorly soluble drugs from aqueous arginine solution

Content Provider	Scilit
Author	Ojarinta, Rami Lerminiaux, Louise Laitinen, Riikka
Copyright Year	2017
Description	Journal: International journal of pharmaceutics Co-amorphous drug-amino acid mixtures have shown potential for improving the solid-state stability and dissolution behaviour of amorphous drugs. In previous studies, however these mixtures have been produced mainly with small-scale preparation methods, or with methods that have required the use of organic solvents or other dissolution enhancers. In the present study, co-amorphous ibuprofen-arginine and indomethacin-arginine mixtures were spray dried from water. The mixtures were prepared at two drug-arginine molar ratios (1:1 and 1:2). The properties of the prepared mixtures were investigated with differential scanning calorimetry, X-ray powder diffractometry, Fourier-transform infrared spectroscopy and a 24h, non-sink, dissolution study. All mixtures exhibited a single glass transition temperature (Tg), evidence of the formation of homogenous single-phase systems. Fourier transform infrared spectroscopy revealed strong interactions (mainly salt formation) that account for the positive deviation between measured and estimated Tg values. No crystallization was observed during a 1-year stability study in either 1:1 or 1:2 mixtures, but in the presence of moisture, handling difficulties were encountered. The formation of co-amorphous salts led to improved dissolution characteristics when compared to the corresponding physical mixtures or to pure crystalline drugs.
Related Links	https://erepo.uef.fi/bitstream/123456789/4317/2/MANUSCRIPT_Final.pdf
Ending Page	298
Page Count	10
Starting Page	289
ISSN	03785173
e-ISSN	18733476
DOI	10.1016/j.ijpharm.2017.09.015
Journal	International journal of pharmaceutics
Issue Number	1
Volume Number	532
Language	English
Publisher	Elsevier BV
Publisher Date	2017-10-01
Access Restriction	Open
Subject Keyword	Journal: International journal of pharmaceutics Pharmacology and Pharmacy
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

Melt extrusion with poorly soluble drugs – An integrated review

Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right?

Increasing Dissolution Rates of Poorly Soluble Drugs by Adsorption to Montnorillonith

Solubility enhancement of poorly aqueous soluble drugs by various techniques

Survival of the Fittest: Time-To-Event Modeling of Crystallization of Amorphous Poorly Soluble Drugs

Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities

Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs

Nanosuspensions: A Formulation Approach for Poorly Soluble and Poorly Bioavailable Drugs

Spray drying of poorly soluble drugs from aqueous arginine solution

Similar Documents

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

Melt extrusion with poorly soluble drugs – An integrated review

Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right?

Increasing Dissolution Rates of Poorly Soluble Drugs by Adsorption to Montnorillonith

Solubility enhancement of poorly aqueous soluble drugs by various techniques

Survival of the Fittest: Time-To-Event Modeling of Crystallization of Amorphous Poorly Soluble Drugs

Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities

Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs

Nanosuspensions: A Formulation Approach for Poorly Soluble and Poorly Bioavailable Drugs

Spray drying of poorly soluble drugs from aqueous arginine solution