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Age-dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged With Swept-Source Optical Coherence Tomography Angiography
| Content Provider | Scilit |
|---|---|
| Author | Zheng, Fang Zhang, Qinqin Shi, Yingying Russell, Jonathan F. Motulsky, Elie H. Banta, James T. Chu, Zhongdi Zhou, Hao Patel, Nimesh A. de Sisternes, Luis Durbin, Mary K. Feuer, William Gregori, Giovanni Wang, Ruikang Rosenfeld, Philip J. |
| Copyright Year | 2019 |
| Description | Journal: American Journal of Ophthalmology Purpose: Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument $(PLEX^{®}$ Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1 mm circle $(C_{1}$), 1.5 mm rim $(R_{1.5}$), and 2.5 mm circle $(C_{2.5}$) from the 3x3 mm and 6x6 mm scans and FD% in the 2.5 mm rim $(R_{2.5}$) and 5 mm circle $(C_{5}$) from the 6x6 mm scans were measured and correlated with age and axial length. Results: A total of 164 subjects were enrolled with at least 10 subjects from each decade of life. No meaningful correlations were found between FD% and axial length (|r| < 0.30). FD% in all fields increased with increasing age (all r > 0.50; all P < 0.001); however, the greatest increases were found in the central macula $C_{1}$ regions and the smallest increases in the peripheral macula $R_{2.5}$ regions. Conclusions: In normal aging, the FD% increased with age across the central 5 mm of the macula, but the greatest increase was found in the central 1 mm region of the macula. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513331/pdf |
| Ending Page | 122 |
| Page Count | 13 |
| Starting Page | 110 |
| ISSN | 00029394 |
| e-ISSN | 18791891 |
| DOI | 10.1016/j.ajo.2018.12.025 |
| Journal | American Journal of Ophthalmology |
| Volume Number | 200 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-01-09 |
| Access Restriction | Open |
| Subject Keyword | Journal: American Journal of Ophthalmology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
