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Disruption of the epithelial barrier during intestinal inflammation: Quest for new molecules and mechanisms
| Content Provider | Scilit |
|---|---|
| Author | Lechuga, Susana Ivanov, Andrei I. |
| Copyright Year | 2017 |
| Description | Journal: Biochimica Et Biophysica Acta (bba) - Molecular Cell Research The intestinal epithelium forms a key protective barrier that separates internal organs from the harmful environment of the gut lumen. Increased permeability of the gut barrier is a common manifestation of different inflammatory disorders contributing to the severity of disease. Barrier permeability is controlled by epithelial adherens junctions and tight junctions. Junctional assembly and integrity depend on fundamental homeostatic processes such as cell differentiation, rearrangements of the cytoskeleton, and vesicle trafficking. Alterations of intestinal epithelial homeostasis during mucosal inflammation may impair structure and remodeling of apical junctions, resulting in increased permeability of the gut barrier. In this review, we summarize recent advances in our understanding of how altered epithelial homeostasis affects the structure and function of adherens junctions and tight junctions in the inflamed gut. Specifically, we focus on the transcription reprogramming of the cell, alterations in the actin cytoskeleton, and junctional endocytosis and exocytosis. We pay special attention to knockout mouse model studies and discuss the relevance of these mechanisms to human gastrointestinal disorders. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507344/pdf |
| Ending Page | 1194 |
| Page Count | 12 |
| Starting Page | 1183 |
| ISSN | 01674889 |
| e-ISSN | 18792596 |
| DOI | 10.1016/j.bbamcr.2017.03.007 |
| Journal | Biochimica Et Biophysica Acta (bba) - Molecular Cell Research |
| Issue Number | 7 |
| Volume Number | 1864 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochimica Et Biophysica Acta (bba) - Molecular Cell Research Gastroenterology and Hepatology Actin Cytoskeleton Adherens Junctions Non-muscle Myosin Ii Tight Junctions |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
