NDLI: Tumor-targeting peptides from combinatorial libraries

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Tumor-targeting peptides from combinatorial libraries

Content Provider	Scilit
Author	Liu, Ruiwu Li, Xiaocen Xiao, Wenwu Lam, Kit S.
Copyright Year	2017
Description	Journal: Advanced Drug Delivery Reviews Cancer is one of the major and leading causes of death worldwide. Two of the greatest challenges in fighting cancer are early detection and effective treatments with no or minimum side effects. Widespread use of targeted therapies and molecular imaging in clinics requires high affinity, tumor-specific agents as effective targeting vehicles to deliver therapeutics and imaging probes to the primary or metastatic tumor sites. Combinatorial libraries such as phage-display and one-bead one-compound (OBOC) peptide libraries are powerful approaches in discovering tumor-targeting peptides. This review gives an overview of different combinatorial library technologies that have been used for the discovery of tumor-targeting peptides. Examples of tumor-targeting peptides identified from each combinatorial library method will be discussed. Published tumor-targeting peptide ligands and their applications will also be summarized by the combinatorial library methods and their corresponding binding receptors.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856482/pdf
Ending Page	37
Page Count	25
Starting Page	13
ISSN	0169409X
e-ISSN	18728294
DOI	10.1016/j.addr.2016.05.009
Journal	Advanced Drug Delivery Reviews
Volume Number	110-111
Language	English
Publisher	Elsevier BV
Publisher Date	2017-02-01
Access Restriction	Open
Subject Keyword	Journal: Advanced Drug Delivery Reviews Pharmacology and Pharmacy Biological Library Cell Surface Receptor High Throughput Screening One-bead One-compound Peptide Library Phage-display Peptide Library Tumor-targeting Peptide
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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