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Effect of dose rate in hypofractionated radiotherapy
| Content Provider | Scilit |
|---|---|
| Author | Kuperman, V. Y. |
| Copyright Year | 2019 |
| Description | Journal: Physica Medica To evaluate how dose rate affects radiobiological properties of hypofractionated radiotherapy. This study is based on the linear-quadratic (LQ) model used to determine biologically effective dose (). Changes in the biologically effective dose in normal tissue () are studied as a function of number of fractions and dose rate under the condition of fixed in the treatment target (. In this study we demonstrate that compared to standard fractionation, hypofractionation can either decrease or increase depending on the average dose rate. In the considered examples, maximum value of in the spinal cord varies monotonically with number of fractions () when dose rate is sufficiently high so that the corresponding fraction time is much smaller than characteristic repair half-lives for malignant and normal cells. In contrast, in the case of a lower dose rate of 300 MU/min, in the cord can vary non-monotonically with . In the later case, there exists optimum number of fractions which corresponds to the minimum . It is shown that in the case when radiation induced sublethal damage is repaired faster in the target than in the affected organ at risk (OAR), increasing dose rate helps lower . We have demonstrated that, as compared to standard fractionation, hypofractionation can either increase or decrease in the OAR depending on the utilized dose rate. Consequently, radiobiological assessment of hypofractionation should take into account dose rate as well as repair rates in the target and OAR. |
| Related Links | http://www.physicamedica.com/article/S1120179719301589/pdf |
| Ending Page | 199 |
| Page Count | 9 |
| Starting Page | 191 |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2019.07.005 |
| Journal | Physica Medica |
| Volume Number | 65 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-09-06 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Biologically Effective Dose Hypofractionation Radiation Protraction |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
