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A new NOE-mediated MT signal at around −1.6ppm for detecting ischemic stroke in rat brain
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Xiao-Yong Wang, Feng Afzal, Aqeela Xu, Junzhong Gore, John C. Gochberg, Daniel F. Zu, Zhongliang |
| Copyright Year | 2016 |
| Description | Journal: Magnetic resonance imaging In the present work, we reported a new nuclear Overhauser enhancement (NOE)-mediated magnetization transfer (MT) signal at around -1.6ppm (NOE(-1.6)) in rat brain and investigated its application in the detection of acute ischemic stroke in rodent model. Using continuous wave (CW) MT sequence, the NOE(-1.6) is reliably detected in rat brain. The amplitude of this new NOE signal in rat brain was quantified using a 5-pool Lorentzian Z-spectral fitting method. Amplitudes of amide, amine, NOE at -3.5ppm (NOE(-3.5)), as well as NOE(-1.6) were mapped using this fitting method in rat brain. Several other conventional imaging parameters (R1, R2, apparent diffusion coefficient (ADC), and semi-solid pool size ratio (PSR)) were also measured. Our results show that NOE(-1.6), R1, R2, ADC, and APT signals from stroke lesion have significant changes at 0.5-1h after stroke. Compared with several other imaging parameters, NOE(-1.6) shows the strongest contrast differences between stroke and contralateral normal tissues and stays consistent over time until 2h after onset of stroke. Our results demonstrate that this new NOE(-1.6) signal in rat brain is a new potential contrast for assessment of acute stroke in vivo and might provide broad applications in the detection of other abnormal tissues. |
| Related Links | http://europepmc.org/articles/pmc4993652?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993652/pdf |
| Ending Page | 1106 |
| Page Count | 7 |
| Starting Page | 1100 |
| ISSN | 0730725X |
| e-ISSN | 18735894 |
| DOI | 10.1016/j.mri.2016.05.002 |
| Journal | Magnetic resonance imaging |
| Issue Number | 8 |
| Volume Number | 34 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic resonance imaging Chemical Exchange Saturation Transfer (cest) Magnetization Transfer (mt) Nuclear Overhauser Enhancement (noe) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Biophysics Biomedical Engineering |
