NDLI: Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells

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Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells

Content Provider	Scilit
Author	Morel, Etienne Ghezzal, Sara Lucchi, Géraldine Truntzer, Caroline de Barros, Jean-Paul Pais Simon-Plas, Françoise Demignot, Sylvie Mineo, Chieko Shaul, Philip W. Leturque, Armelle Rousset, Monique Carrière, Véronique
Copyright Year	2018
Description	Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent lipid sensing is associated with SR-B1 recruitment in raft-like/ detergent-resistant membrane domains and interaction of its C-terminal transmembrane domain with plasma membrane cholesterol. To clarify the initiating events occurring during lipid sensing by SR-B1, we analyzed cholesterol trafficking and raft-like domain composition in intestinal epithelial cells expressing wild-type SR-B1 or the mutated form SR-B1-Q445A, defective in membrane cholesterol binding and signal initiation. These features of SR-B1 were found to influence both apical cholesterol efflux and intracellular cholesterol trafficking from plasma membrane to lipid droplets, and the lipid composition of raft-like domains. Lipidomic analysis revealed likely participation of d18:0/16:0 sphingomyelin and 16:0/0:0 lysophosphatidylethanolamine in lipid sensing by SR-B1. Proteomic analysis identified proteins, whose abundance changed in raft-like domains during lipid sensing, and these included molecules linked to lipid raft dynamics and signal transduction. These findings provide new insights into the role of SR-B1 in cellular cholesterol homeostasis and suggest molecular links between SR-B1-dependent lipid sensing and cell cholesterol and lipid droplet dynamics.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742559/pdf
Ending Page	211
Page Count	13
Starting Page	199
ISSN	13881981
e-ISSN	18792618
DOI	10.1016/j.bbalip.2017.11.009
Journal	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Issue Number	2
Volume Number	1863
Language	English
Publisher	Elsevier BV
Publisher Date	2018-02-01
Access Restriction	Open
Subject Keyword	Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Biochemistry and Molecular Biology Lipid Trafficking Scavenger Receptor
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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