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A highly immunogenic vaccine against A/H7N9 influenza virus
| Content Provider | Scilit |
|---|---|
| Author | Cao, Weiping Liepkalns, Justine S. Hassan, Ahmed O. Kamal, Ram P. Hofstetter, Amelia R. Amoah, Samuel Kim, Jin Hyang Reber, Adrian J. Stevens, James Katz, Jacqueline M. Gangappa, Shivaprakash Mittal, Suresh K. Sambhara, Suryaprakash |
| Copyright Year | 2016 |
| Description | Journal: Vaccine Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine. |
| Related Links | http://europepmc.org/articles/pmc4735641?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735641/pdf |
| Ending Page | 749 |
| Page Count | 6 |
| Starting Page | 744 |
| ISSN | 0264410X |
| DOI | 10.1016/j.vaccine.2015.12.062 |
| Journal | Vaccine |
| Issue Number | 6 |
| Volume Number | 34 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-01-04 |
| Access Restriction | Open |
| Subject Keyword | Journal: Vaccine A/h7n9 Influenza Vaccine Adenoviral Vector Vaccine Cell-mediated Immunity Antibody Responses Protective Immunity Mouse Model |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Microbiology Veterinary Public Health, Environmental and Occupational Health Molecular Medicine |
