Relationship between antibiotic- and disinfectant-resistance profiles in bacteria harvested from tap water

Content Provider	Scilit
Author	Khan, Sadia Beattie, Tara K. Knapp, Charles W.
Copyright Year	2016
Description	Journal: Chemosphere Chlorination is commonly used to control levels of bacteria in drinking water; however, viable bacteria may remain due to chlorine resistance. What may be concerning is that surviving bacteria, due to co-selection factors, may also have increased resistance to common antibiotics. This would pose a public health risk as it could link resistant bacteria in the natural environment to human population. Here, we investigated the relationship between chlorine- and antibiotic-resistances by harvesting 148 surviving bacteria from chlorinated drinking-water systems and compared their susceptibilities against chlorine disinfectants and antibiotics. Twenty-two genera were isolated, including members of Paenibacillus, Burkholderia, Escherichia, Sphingomonas and Dermacoccus species. Weak (but significant) correlations were found between chlorine-tolerance and minimum inhibitory concentrations against the antibiotics tetracycline, sulfamethoxazole and amoxicillin, but not against ciprofloxacin; this suggest that chlorine-tolerant bacteria are more likely to also be antibiotic resistant. Further, antibiotic-resistant bacteria survived longer than antibiotic-sensitive organisms when exposed to free chlorine in a contact-time assay; however, there were little differences in susceptibility when exposed to monochloramine. Irrespective of antibiotic-resistance, spore-forming bacteria had higher tolerance against disinfection compounds. The presence of chlorine-resistant bacteria surviving in drinking-water systems may also carry additional risk of antibiotic resistance
Related Links	https://strathprints.strath.ac.uk/55632/1/Khan_Beattie_Knapp_C2016_relationship_between_antibiotic_and_disinfectant_resistance_profiles.pdf https://core.ac.uk/download/pdf/110682834.pdf
Ending Page	141
Page Count	10
Starting Page	132
ISSN	00456535
e-ISSN	18791298
DOI	10.1016/j.chemosphere.2016.02.086
Journal	Chemosphere
Volume Number	152
Language	English
Publisher	Elsevier BV
Publisher Date	2016-06-01
Access Restriction	Open
Subject Keyword	Journal: Chemosphere Water Science and Technology Antibiotic Resistance Genes Antibiotic-resistant Bacteria Antimicrobial-resistant Bacteria Deoxyribonucleic Acid Disinfectant-resistance N,n-diethyl-p-phenylenediamine Phosphate Buffer Saline Polymerase Chain Reaction
Content Type	Text
Resource Type	Article
Subject	Chemistry Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Public Health, Environmental and Occupational Health Environmental Engineering