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Treatment of Kaposi Sarcoma Herpesvirus–Associated Multicentric Castleman Disease
| Content Provider | Scilit |
|---|---|
| Author | Lurain, Kathryn Yarchoan, Robert Uldrick, Thomas S. |
| Copyright Year | 2017 |
| Description | Journal: Hematology/oncology clinics of North America Kaposi sarcoma herpes virus (KSHV)-associated multicentric Castleman disease (MCD) is a rare, polyclonal lymphoproliferative disorder characterized by flares of inflammatory symptoms, edema, cytopenias, lymphadenopathy and splenomegaly. Diagnosis is established with a lymph node biopsy. Pathogenesis is related to dysregulated inflammatory cytokines, including human and viral interleukin (IL)-6. Rituximab alone or in combination with chemotherapy, such as liposomal doxorubicin, has led to long-term overall survival of over 90%. Monoclonal antibodies targeting human interleukin-6 activity remain experimental as they do not target viral interleukin-6. KSHV-MCD patients are at high risk for Kaposi sarcoma and non-Hodgkin lymphomas, which may be concurrent. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726416/pdf |
| Ending Page | 88 |
| Page Count | 14 |
| Starting Page | 75 |
| ISSN | 08898588 |
| e-ISSN | 15581977 |
| DOI | 10.1016/j.hoc.2017.09.007 |
| Journal | Hematology/oncology clinics of North America |
| Issue Number | 1 |
| Volume Number | 32 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hematology/oncology clinics of North America Infectious Diseases Kaposi Sarcoma Herpesvirus Human Herpesvirus-8 Multicentric Castleman Disease Human Interleukin-6 Viral Interleukin 6 Liposomal Doxorubicin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Oncology |
