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Serum β-Trace Protein and β2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study
| Content Provider | Scilit |
|---|---|
| Author | Foster, Meredith C. Coresh, Josef Hsu, Chi-Yuan Xie, Dawei Levey, Andrew S. Nelson, Robert G. Eckfeldt, John H. Vasan, Ramachandran S. Kimmel, Paul L. Schelling, Jeffrey Simonson, Michael Sondheimer, James H. Anderson, Amanda Hyre Akkina, Sanjeev Feldman, Harold I. Kusek, John W. Ojo, Akinlolu O. Inker, Lesley A. Appel, Lawrence J. Go, Alan S. He, Jiang Lash, James P. Rahman, Mahboob Townsend, Raymond R. |
| Copyright Year | 2016 |
| Description | Journal: American Journal of Kidney Diseases Background Serum β-trace protein (BTP) and $β_{2}$-microglobulin (B2M) are independently associated with end-stage renal disease (ESRD) and mortality in the general population and high-risk groups with diabetes or advanced chronic kidney disease (CKD). Less is known about their associations with outcomes and predictive ability in adults with moderate CKD. Study Design Prospective cohort study. Setting & Participants 3,613 adults from the CRIC (Chronic Renal Insufficiency Cohort) Study (45% women; mean age, 57.9 years; 41.0% non-Hispanic black; 51.9% with diabetes). Predictors BTP and B2M levels with a reciprocal transformation to reflect their associations with filtration, creatinine-based estimated glomerular filtration rate $(eGFR_{cr}$), measured GFR, and a 4-marker composite score combining BTP, B2M, creatinine, and cystatin C levels. Predictors were standardized as z scores for comparisons across filtration markers. Outcomes ESRD, all-cause mortality, and new-onset cardiovascular disease. Results During a 6-year median follow-up, 755 (21%) participants developed ESRD, 653 died, and 292 developed new-onset cardiovascular disease. BTP, B2M, and the 4-marker composite score were independent predictors of ESRD and all-cause mortality, and B2M and the 4-marker composite score of cardiovascular events, after multivariable adjustment. These associations were stronger than those observed for $eGFR_{cr}$ (P vs $eGFR_{cr}$≤0.02). The 4-marker composite score led to improvements in C statistic and 2.5-year risk reclassification beyond $eGFR_{cr}$ for all outcomes. Limitations Filtration markers measured at one time point; measured GFR available in subset of cohort. Conclusions BTP and B2M levels may contribute additional risk information beyond $eGFR_{cr}$, and the use of multiple markers may improve risk prediction beyond this well-established marker of kidney function among persons with moderate CKD. |
| Related Links | http://europepmc.org/articles/pmc4921300?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921300/pdf http://www.ajkd.org/article/S0272638616001311/pdf |
| Ending Page | 76 |
| Page Count | 9 |
| Starting Page | 68 |
| ISSN | 02726386 |
| e-ISSN | 15236838 |
| DOI | 10.1053/j.ajkd.2016.01.015 |
| Journal | American Journal of Kidney Diseases |
| Issue Number | 1 |
| Volume Number | 68 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: American Journal of Kidney Diseases Endocrinology and Metabolism Beta-trace Protein (btp) Β2-microglobulin (b2m) Ckd Biomarkers Consortium Filtration Markers Renal Function Estimated Glomerular Filtration Rate (egfr) Chronic Kidney Disease (ckd) End-stage Renal Disease (esrd) Cardiovascular Events Chronic Renal Insufficiency Cohort (cric) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
