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The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
| Content Provider | Scilit |
|---|---|
| Author | Wang, Qiong Zou, Yilong Nowotschin, Sonja Kim, Sang Yong Li, Qing V. Soh, Chew-Li Su, Jie Zhang, Chao Shu, Weiping Xi, Qiaoran Huangfu, Danwei Hadjantonakis, Anna-Katerina Massagué, Joan |
| Copyright Year | 2016 |
| Description | Journal: Cell Stem Cell Summary In this study, we outline a regulatory network that involves the p53 tumor suppressor family and the Wnt pathway acting together with the TGF-β pathway in mesendodermal differentiation of mouse and human embryonic stem cells. Knockout of all three members, p53, p63, and p73, shows that the p53 family is essential for mesendoderm specification during exit from pluripotency in embryos and in culture. Wnt3 and its receptor Fzd1 are direct p53 family target genes in this context, and induction of Wnt signaling by p53 is critical for activation of mesendodermal differentiation genes. Globally, Wnt3-activated Tcf3 and nodal-activated Smad2/3 transcription factors depend on each other for co-occupancy of target enhancers associated with key differentiation loci. Our results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs in a selective and interdependent way to drive mesendodermal differentiation of pluripotent cells. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218926/pdf http://www.cell.com/article/S1934590916303423/pdf |
| Ending Page | 86 |
| Page Count | 17 |
| Starting Page | 70 |
| ISSN | 19345909 |
| e-ISSN | 18759777 |
| DOI | 10.1016/j.stem.2016.10.002 |
| Journal | Cell Stem Cell |
| Issue Number | 1 |
| Volume Number | 20 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-11-23 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Stem Cell Cell Tissue Engineering P53 Tumor Suppressor Mesendoderm Differentiation Embryonic Stem Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Molecular Medicine |
