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A mechanism for propagated SOD1 misfolding from frustration analysis of a G85R mutant protein assembly
| Content Provider | Scilit |
|---|---|
| Author | Healy, Eamonn F. |
| Copyright Year | 2016 |
| Description | Journal: Biochemical and Biophysical Research Communications Application of landscape theory and the dehydron hypothesis to a crystal structure of a G85R mutant superoxide dismutase (SOD1) tetrameric complex allows for the description of a prion-like hypothesis that serves to explain propagated SOD1 misfolding. We have developed two conformational-change scenarios, one local to the ESL at the complex interface, and a second displacement at the ESL of the otherdimeric subunit. When taken together these provide for a prion-like mechanism that can serve to explain the observed conversion of wtSOD1 to a misfolded form by the G85R mutant. |
| Related Links | http://europepmc.org/articles/pmc5030186?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030186/pdf |
| Ending Page | 1639 |
| Page Count | 6 |
| Starting Page | 1634 |
| ISSN | 0006291X |
| e-ISSN | 10902104 |
| DOI | 10.1016/j.bbrc.2016.08.172 |
| Journal | Biochemical and Biophysical Research Communications |
| Issue Number | 4 |
| Volume Number | 478 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-08-31 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochemical and Biophysical Research Communications Biochemistry and Molecular Biology Superoxide Dismutase Amyotrophic Lateral Sclerosis Electrostatic Loop G85r Sod1 Mutant Frustration Contacts |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Biochemistry Biophysics |
