NDLI: Research Techniques Made Simple: Using Genome-Wide Association Studies to Understand Complex Cutaneous Disorders

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Research Techniques Made Simple: Using Genome-Wide Association Studies to Understand Complex Cutaneous Disorders

Content Provider	Scilit
Author	Tsoi, Lam C. Patrick, Matthew T. Elder, James T.
Copyright Year	2018
Description	Journal: Journal of Investigative Dermatology Complex cutaneous disorders result from the combined effect of many different genes and environmental factors, with individual genetic variants often having only a modest effect on disease risk. The ability to examine large numbers of samples is required for correlating genetic variants with diseases/traits. Technological advances in high-throughput genotyping, along with mapping of the human genome and its associated inter-individual variation, have allowed genetic variants to be analyzed at high density in large case-control cohorts for many diseases, including several major skin diseases. These genome-wide association studies focus on showing differences in the frequencies of variants between case and control groups, rather than co-transmission of a variant and disease through a family, as is done in linkage studies. In this review, we provide overall guidance for genome-wide association study analysis and interpreting the results. Additionally, we discuss challenges and future directions for genome-wide association studies, focusing on translation of findings to provide biological and clinical implications for dermatology.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903459/pdf http://www.jidonline.org/article/S0022202X18300216/pdf
Ending Page	e29
Page Count	7
Starting Page	e23
ISSN	0022202X
e-ISSN	15231747
DOI	10.1016/j.jid.2018.01.004
Journal	Journal of Investigative Dermatology
Issue Number	3
Volume Number	138
Language	English
Publisher	Elsevier BV
Publisher Date	2018-03-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Investigative Dermatology Gwas; Genome-wide Association Study
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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