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Dynamic pattern generation in cell membranes: Current insights into membrane organization
| Content Provider | Scilit |
|---|---|
| Author | Raghunathan, Krishnan Kenworthy, Anne K. |
| Copyright Year | 2018 |
| Description | Journal: Biochimica Et Biophysica Acta (bba) - Biomembranes It has been two decades since the lipid raft hypothesis was first presented. Even today, whether these nanoscale cholesterol-rich domains are present in cell membranes is not completely resolved. However, especially in the last few years, a rich body of literature has demonstrated both the presence and the importance of non-random distribution of biomolecules on the membrane, which is the focus of this review. These new developments have pushed the experimental limits of detection and have brought us closer to observing lipid domains in the plasma membrane of live cells. Characterization of biomolecules associated with lipid rafts has revealed a deep connection between biological regulation and function and membrane compositional heterogeneities. Finally, tantalizing new developments in the field have demonstrated that lipid domains might not just be associated with the plasma membrane of eukaryotes but could potentially be a ubiquitous membrane-organizing principle in several other biological systems. This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by Marjorie Longo. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234104/pdf |
| Ending Page | 2031 |
| Page Count | 14 |
| Starting Page | 2018 |
| ISSN | 00052736 |
| DOI | 10.1016/j.bbamem.2018.05.002 |
| Journal | Biochimica Et Biophysica Acta (bba) - Biomembranes |
| Issue Number | 10 |
| Volume Number | 1860 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochimica Et Biophysica Acta (bba) - Biomembranes Bacterial Toxins Immune Receptor Clustering Lipid Rafts Membrane Domains Super-resolution Fluorescence Microscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Biophysics |
