NDLI: Bioresorbable silk grafts for small diameter vascular tissue engineering applications: In vitro and in vivo functional analysis

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Bioresorbable silk grafts for small diameter vascular tissue engineering applications: In vitro and in vivo functional analysis

Content Provider	Scilit
Author	Gupta, Prerak Lorentz, Katherine L. Haskett, Darren G. Cunnane, Eoghan M. Ramaswamy, Aneesh K. Weinbaum, Justin S. Vorp, David A. Mandal, Biman B.
Copyright Year	2020
Description	Journal: Acta Biomaterialia The success of tissue-engineered vascular graft (TEVG) predominantly relies on the selection of a suitable biomaterial and graft design. Natural biopolymer silk has shown great promise for various tissue-engineering applications. This study is the first to investigate Indian endemic non-mulberry silk (Antheraea assama-AA) – which inherits naturally superior mechanical and biological traits (e.g., RGD motifs) compared to Bombyx mori-BM silk, for TEVG applications. We designed bi-layered biomimetic small diameter AA-BM silk TEVGs adopting a new fabrication methodology. The inner layer showed ideally sized (~40 µm) pores with interconnectivity to allow cellular infiltration, and an outer dense electrospun layer that confers mechanical resilience. Biodegradation of silk TEVGs into amino acids as resorbable byproducts corroborates their in vivo remodeling ability. Following our previous reports, we surgically implanted human adipose tissue-derived stromal vascular fraction (SVF) seeded silk TEVGs in Lewis rats as abdominal aortic interposition grafts for 8 weeks. Adequate suture retention strength (0.45 ± 0.1 N) without any blood seepage post-implantation substantiate the grafts’ viability. AA silk-based TEVGs showed superior animal survival and graft patency compared to BM silk TEVGs. Histological analysis revealed neo-tissue formation, host cell infiltration and graft remodeling in terms of extracellular matrix turnover. Altogether, this study demonstrates promising aspects of AA silk TEVGs for vascular tissue engineering applications.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050402/pdf
Ending Page	158
Page Count	13
Starting Page	146
ISSN	17427061
e-ISSN	18787568
DOI	10.1016/j.actbio.2020.01.020
Journal	Acta Biomaterialia
Volume Number	105
Language	English
Publisher	Elsevier BV
Publisher Date	2020-01-17
Access Restriction	Open
Subject Keyword	Journal: Acta Biomaterialia Non-mulberry Silk Tissue Engineering Tissue Remodeling
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology

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