NDLI: Microfluidic models for adoptive cell-mediated cancer immunotherapies

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Microfluidic models for adoptive cell-mediated cancer immunotherapies

Content Provider	Scilit
Author	Adriani, Giulia Pavesi, Andrea Tan, Anthony T. Bertoletti, Antonio Thiery, Jean Paul Kamm, Roger D.
Copyright Year	2016
Description	Journal: Drug Discovery Today Current adoptive T cell therapies have shown promising results in clinical trials but need further development as an effective cancer treatment. Here, we discuss how 3D microfluidic tumour models mimicking the tumour microenvironment could help in testing T cell immunotherapies by assessing engineered T cells and identifying combinatorial therapy to improve therapeutic efficacy. We propose that 3D microfluidic systems can be used to screen different patient-specific treatments, thereby reducing the burden of in vivo testing and facilitating the rapid translation of successful T cell cancer immunotherapies to the clinic.
Related Links	https://dspace.mit.edu/bitstream/1721.1/119471/1/nihms-786883.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035566/pdf
Ending Page	1478
Page Count	7
Starting Page	1472
ISSN	13596446
e-ISSN	18785832
DOI	10.1016/j.drudis.2016.05.006
Journal	Drug Discovery Today
Issue Number	9
Volume Number	21
Language	English
Publisher	Elsevier BV
Publisher Date	2016-09-01
Access Restriction	Open
Subject Keyword	Journal: Drug Discovery Today Research and Experimental Medicine Adoptive Cell Therapy Cancer Immunotherapy
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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